The research paper explores the operational activities of drug law enforcement (DLE) in Zambia from the perspective of seasoned agents within the Drug Enforcement Commission (DEC). Utilizing in-depth interviews with experienced anti-drug agents, the research captured insights through recorded, transcribed, and thematically analyzed conversations, highlighting key findings and challenges in the fight against drug-related issues. The findings of the research study establish that DLE’s gatekeeping role is firmly embedded in Zambia’s existing legal and policy framework, which serves as the cornerstone for anti-drug efforts. However, significant challenges emerged, particularly regarding institutional synergies. Weak or nonexistent collaboration among key stakeholders undermined the prescribed multidisciplinary approach, rendering the nation’s drug control efforts largely ineffective. Additionally, the research paper revealed a persistent reliance on traditional drug demand and supply interventions, which are often hampered by insufficient logistical support, including inadequate equipment. To address these shortcomings, the study proposed several recommendations. These include, among others, regular research initiatives by the DEC to understand evolving drug trends, the establishment of a national multidisciplinary steering task force to enhance policy implementation, and the adoption of a more robust and context-appropriate operational model. By addressing these gaps, the effectiveness of Zambia's drug law enforcement operations could be significantly improved.