Introduction: Globally, 1.7-2.5 million episodes of diarrhoea occur in children less than 5 years of age per annum. Diarrhoea is also responsible for at least 500,000 childhood deaths annually.

Methodology: This was a cross-sectional study conducted amongst mothers whose children were receiving care in the children’s out-patient clinic of Edo Specialist Hospital. Maternal knowledge of diarrhoea disease and their practice during diarrhoea disease were assessed using pre-tested questionnaires.

Results: Nearly half of the respondents (49.31%) were within the age of 30-39 years. Majority of the respondents (87.3%) had good knowledge of the causes of diarrhoea (87.3%), whole less than half of respondents (48.7%) had good knowledge of the danger signs of diarrhoea. No association was found between the level of education and overall knowledge of diarrhoea.

Conclusion: Although majority of the respondents had good knowledge of the causes of diarrhoea, however, they overall knowledge of diarrhoea amongst the mother was low. This is a cause of concern as this might negatively affect the morbidity statistics from diarrhoea in our environment.