Warehouses have played an essential role in operating production as well as services. Therefore, scientists have constantly researched and developed simple, low-cost, and effective warehouse operation models to reduce storage costs while maintaining uncertain demands. Company G. is an e-commerce company that distributes a wide range of products with its focused market in the southern region of Vietnam. The company is having problems in warehouse management that affect the accomplishment of its goals and its ability to compete with other companies. This study proposes a set of solutions consisting of methods to change the layout of goods in the warehouse, standardize the warehouse management process, and design an information system to support inventory management to increase operational efficiency. These solutions have begun to be implemented at the company and have shown some positive signals.