A 10-week feeding trial was conducted to investigate the effect of different combinations of three protein sources (Fish meal, Soybean Meal and Groundnut Cake) on the growth performance of guinea fowl using thirty-two 12- week old growing keets on their growth performance and carcass yields. The birds were randomly distributed in a completely randomized design into four dietary treatments (eight keets per treatment). The proteins were combined as fish meal, soybean meal and groundnut cake (control), fish meal and soybean meal, fish meal and groundnut cake, groundnut cake and soybean meal in treatments 1, 2, 3 and 4 respectively. Parameters measured were total feed intake, average weight gain, and feed conversion ratio. At the end of 10 weeks, 2 birds per treatment were randomly selected, weighed and slaughtered for carcass assessment. Results showed that treatment significantly influenced (p<0.05) the average weight gain, total feed intake and feed conversion ratio. No significant difference (p>0.05) in final weight though T2 had the highest final weight (1152.11g). Total feed intake was significantly different (p<0.05) with least value 1113.83g recorded from T1, The lowest or the best feed conversion ratio was recorded from T2 (2.28) and the result is statistically (p<0.05) different. The breast muscle and abdominal fat were statistically different (p<0.05) with T2 having the highest percentage of breast muscle (29.98%) and also had the lowest percentage of abdominal fat (0.63%). The results showed that the birds performed best on diet T2- (soybean meal and fish meal) than every other diets. The use of fish meal and soybean meal combination could therefore be recommended for guinea fowl diet formulation especially for the growing keets.