Carefully when we observed people around, we discovered a lot of differences in our behaviors. While some are quiet, others maybe talkative. Similarly, some worry a lot, others almost never seem anxious. Each time we classify people as either talkative or quiet or active or anxious, we are referring to individual’s personality trait. These traits were conceptualized in a Big 5 model to comprise of openness, conscientiousness, extraversion, agreeableness and neuroticism. This research was tailored towards measuring the effects of these traits on gender enrolment in entrepreneurship. For effective data presentation and analysis, descriptive statistics, simple percentages and mean were employed. Data obtained for this study was through well structured questionnaires. Out of 500 questionnaires administered, only 475 questionnaires were correctly filled and returned, representing 95% of response rate across the three major metropolises in Local Government. With an average mean score of 3.72, it was admitted that men has high trait of openness than woman while an average mean score of 2.91 shows that women possess high trait of conscientiousness than men. Average mean scores of 3.72; 3.56 and 3.98 respectively show gender’s behavior in terms of extraversion, agreeableness and neuroticism. These values indicate that men are more extraverts, agreeable and neurotic than women which enhanced their enrolment in entrepreneurship. This study concluded that, although traits are combination of genetic and environmental factors, men and women should be taken through entrepreneurship education designed with various skill acquisition programs to enhance their enrolment.