Ama is considered as Back Bone of all disease explained under Sastra. If definitionally speaking, "Ushmano Alpa Balatwena Dhaturmadya Apachitam. Dushtam Amasaya gatam Rasam Amam Prachakshate" (Due to Alpabala of agni, the Sarabhaga of Rasa dhatu & the annarasa which is consumed by an individual does not go proper digestion, the by product of this process is known as Ama]. But if we think beyond the definitions, we have to understand that the anomalies that occur in any evolutionary process of the body causes AMA. What are all the disease which caused due to metabolism, it is nothing differs from Ama. Then we can consider this Ama is cause of all disease. Understanding & Analysis is much more important than realizing Ama is the causative factor of a particular disease. Most of the lifestyle and auto immune diseases mainly occurs due to this ama only. Proper analysis of ama gives us an innovative window to the therapeutic spectrum.