The main objective of the study is to examine the effects of quality of accounting information system on profitability of Guaranty Trust Bank Plc Road Branch Kano state. This study used multiple regression and descriptive statistical techniques, i.e. using tables, frequencies, and percentages as well as mean and standard deviation to analyse the demographical features of the respondents while inferential statistics was used to determine the influence of independent variables (relevance, reliability, comparability, understandability, consistency and neutrality of accounting information system,) on the dependent variable (profitability), the study used SPSS version 22.0 to analyse the data. The result of the study revealed that all the six proxies of quality of accounting information system significantly influence profitability of Guaranty Trust Bank Plc, therefore the study recommends that accounting information management should be targeted more and seen as real reform in the banking industry so as to promote economic development in Nigeria. The study also recommends that the use of computerized accounting information systems effectively in all the company's activities so as to ensure the desired benefits of accounting information systems, which has many of the companies for which to sacrifice many of their resources in order to obtain these systems.