Innovation and entrepreneurship education is a brand-new educational concept, which aims to cultivate applied talents with innovative spirit, innovative consciousness and innovative and entrepreneurial ability. Taking Zhejiang Normal University as an example and analyzing its school running characteristics, this paper constructs a multi-level three-dimensional innovation and entrepreneurship education system, including the target system, curriculum system, practice system, guarantee system and evaluation system, in order to provide theoretical guidance and practical countermeasures for comprehensively deepening the innovation and entrepreneurship education reform of Local Universities.