Hypothyroidism is commanest endocrine disease. It affects quality of life of individual. In Modern medicine, Only treatment is synthetic thyroxine tablets which patients had to take lifelong.

The Phenomena of Ama as understand like outcome of improper digestion. Samagni is result of equilibrated states of functioning of tridoshas. Agni plays an important role in digestion of food as well as it maintain hormonal mechanisms. Thyroid Function largely depends on GIT health. Hypo, Hyper and Erractic function of agni may be followed by hypo, hyper and erractic function of thyroid gland. So hypothyroidism can be considered as a result of ama formation which is caused by agnimandya.