The objective of study is to find out effects of online classes on Bio- Psycho-Social Health issues of children in West Siang District, Arunachal Pradesh. Descriptive survey Method was used for this study and Five (5) Private Upper- primary Schools used as population from Aalo, West Siang District, Arunachal Pradesh (randomly selection of 25 each boys and girls from class 6 and 7) were used as sample for study. Self-prepared Questionnaire, Interview and Observation Techniques were used as tools for data collection. The data were analysed in simple Percentage Method. The study found in three categories - Category 1 (Physical issues): 9.5% of students having high eyesight problem whereas 9.55 average and 81% low eyesight problem.10% of students having high lack of classroom ethics whereas 71% average and 19% low lack of classroom ethics. 25% of students having high lack of physical activities whereas 35% average and 40% low lack of physical activities.22% of students having high lack of vitamin D whereas 30% average and 48% low lack of vitamin D. Category 2 (Mental issues): 32% of students having high lack of interest whereas 63% of students average and 5% of students low.10% of students having high stress and anxiety whereas 36% average and 54% low stress and anxiety. 10% of students having high zoom fatigue whereas 26% average and 64% low zoom fatigue. Category 3 (Social issues): no students Face to Face Interaction with Teachers, Playing with Friends and Face to Face Interaction with relatives during Pandemic i.e. 100% students confined at home. All Parents and Teachers should follow the new guidelines of Covid-19 Protocols released by WHO and UNICEF to keep children safe and preventable from harms coming during online classes.