The crude extracts of Bennincas Hispida i.e. ethanolic extract and aqueous extract were studied for the presence and detection of phytochemical such as of flavonoids, sterols, terpenoids, carbohydrates and phenolic compounds using standard procedures. On the basis of the results, the extracts were further used for in vivo evaluation of antidiabetic activity. The present study was designed to study the phytochemical screening and to investigate the antidiabetic potential of aqueous and ethanolic extract of dried leaves of Bennincas Hispida. The antidiabetic potential was evaluated by Streptozotocin-Nicotinamide induced diabetic in rat model. The extracts showed significant potential in a dose dependant manner when compared with the Glibenclamide. The aqueous extract shows good glucose lowering ability than ethanoloc extract on day 15. Thus both the ME and AE may be useful as a natural antioxidants in the near future.