Small and medium-sized enterprises (SMEs) play an important role in socio-economic development, contributing significantly to GDP, creating jobs, and stabilizing the economy. Compared to other countries in the region and the world, Vietnamese SMEs still have many limitations in terms of scale and contribution levels and have not yet fully brought into play their full potential (Phung The Dong, 2019). However, recent studies indicate that SMEs are more likely to fail than large firms, even though they are often seen as important internal drivers of a country's economy (Bloch and Bhattacharya, 2016; Lo et al, 2016). According to Gnizy et al (2014), characteristics including: resource constraints, informal strategy, inflexible structure and lack of strategic planning processes may have contributed to the failure of surname. Recent studies suggest that if we can better understand why small and medium businesses fail, we should be able to increase the odds of success. However, it has proven extremely difficult to predict which factors will succeed and fail. This has recently become a hot topic because it has been difficult for researchers to explain and predict why some firms succeed and others fail (Olaison & Sorensen, 2014). In this study, the author has found out factors such as: Social responsibility, Government support, finance, management, marketing ability, access to technology innovation, have a positive impact on the success of SMEs in Southeastern provinces