Competitiveness affecting business results of enterprises is a research topic of great interest, especially among enterprises operating in the field of e-commerce in Ho Chi Minh City (Nha and Lien, 2015). The competitiveness of enterprises is the determining factor in the business results of the organization (Tran Thi Anh Thu, 2012). This paper aims to systematize the theoretical basis as well as identify the factors of the research model of competitiveness in e-commerce enterprises in Ho Chi Minh City. The article mainly uses quantitative research methods with tools such as exploratory factor analysis (EFA), confirmatory factor analysis (CFA) as well as linear structural model SEM. The results of the paper are an important part of the author's research during his PhD studentship at Saigon International University.