Antibiotic resistance is a global health concern as it is one of the biggest threats to global health, food security and development today. Many different infectious diseases that were once easily treated with different brands of antibiotics are becoming more difficult to treat. The world Health Organization (WHO) estimated that around 700,000 people die yearly around the globe from diseases caused by bacteria that have developed antibiotic resistance and that if the current trend persists, the problem could kill 10 million people every year by 2050, making antimicrobial resistance more dangerous than diabetes, tuberculosis and HIV AIDS combined. Typhoid fever is prevalent in Nigeria and its taking a toll on the overall socioeconomic well-being of the populace. Data on antibiotic resistance pattern is very limited due to lack of comprehensive surveillance strategies The problem needs to be addressed urgently through research and development, as the country has one of the least comprehensive surveillance strategies for antibiotic resistance of all world regions alongside scarce infection prevention and control programs. This study aimed to detect multidrug resistant (MDR) salmonella typhi. A total of 150 patients blood samples from both males and females were collected and analysed. Salmonella isolates were confirmed and among them 5 were confirmed to be Salmonella enterica serovar typhi using biochemical and serological methods. Kirby Bauer disc diffusion antibiotics susceptibility testing was performed and it revealed the salmonella isolates exhibit multidrug resistance (MDR) with tetracycline showing the highest resistance (100%) followed by ampicillin and amoxicillin at 83.3% and 66.67% respectively. Lowest resistance was observed against ciprofloxacin and gentamicin while the isolates were moderately resistant to ofloxacin and doxycycline.