This study focused on multinational company MNCs activities as it affects Nigeria economic growth from 2015 to 2021. The explanatory variables include MNCs: technological development TDEV; employment creation EMLC; and investment INVT; while the dependent variable is real gross domestic products RGDP. The nature of the research design is ex-post-facto research that obtained secondary data from Central Bank of Nigeria Statistical Bulletin and National Bureau of Statistics covering the periods. Population of the study consists of the 30 MNCs listed as at 31st December, 2021. Sample size was 14 MNCs based on the judgmental sampling techniques. The analyses models adapted: Descriptive Statistics, Pearson Correlation, Variance Inflation Factor VIF and Multiple Regression. The models’ results show that the MNCs activities predicted about 37% and 34% of R-squared and Adjust. R-squared found in RGDP in Nigeria; while the rest were explained by other factors outside the scope of the study. Finally, MNCs INVT is positive and statistically significant; while TDEV and EMLC are negative and statistically significant on RGDP in Nigeria within the study periods. The study recommends that the government should advice the MNCs to increase investment, employment and improve on TDEV in Nigeria. This study contributes to the existing body of knowledge with: the positive impact of the three variables applied; the modernized model of the study, the empirical findings and the rich literature for academia. Implications of the study result are that the findings were based on selected MNCs in Nigeria and care should be taken in generalizing the results in other countries.