The study was carried out to compare the efficacy of Moringa olefeira seed and Potassium aluminium sulphate in remediation of effluent from the Nigerian Brewery, Kaduna. Treatment with both coagulants showed significant reductions in pH values in the treatment groups compared with the control group. From the physicochemical analyses, there was no significant difference at (P > 0.05) in the treatment groups compared with the control group. There was a significant decrease at (P < 0.05) in the values of all parameters in the entire treatment groups compared with the control group, and the effectiveness of the reduction is dose specific i.e. the higher the doses, the more effective the performance. Results from bacteriological analyses after treatment with 1g, 3g, 5g and 7g of Moringa oleifera seed revealed 1.8 x 104cfu/ml, 1.5 x104cfu/ml, 1 x 103cfu/ml and 0cfu/ml respectively from total bacterial count and 2MPN, <2MPN, <2MPN and <2MPN respectively from enumeration of total coliform. Treatment with Potassium aluminium sulphate revealed 2.6 x 104cfu/ml, 2 x 104cfu/ml, 1.8 x 104cfu/ml and 1.5 x 104cfu/ml respectively, from the total bacterial count and 1600MPN, 62MPN, 40MPN and 29MPN respectively, from the enumeration of total and feacal coliforms. The average bacterial count showed a significant difference at (P < 0.05) that existed between the coagulants doses as they related to bacterial recovery. The microorganism isolated from the effluent sample was Proteus mirabilis. From the above results, Moringa oleifera seed was found to be more effective in treating the effluent sample than Potassium aluminium sulphate.