This paper deals with the foundation of the theory of Architecturally Defined Space (ADS), its testing through a series of published books and scientific papers, and, finally, its subjection to testing by 'artificial intelligence'. It was a long and exciting journey of the author, which started from the Balkans (where he tested his theory on the example of the town house of the Oriental team), the analysis of a large number of examples of vernacular architecture (primarily in the area of Bosnia and Herzegovina), the analysis of individual architectural realizations in the area Balkans, Mediterranean, Central and Western Europe and some examples from the Middle East, Turkey and Malaysia, studies of architecture (as a framework for life) in extreme climatic environments on Earth, studies of architecture and urbanism along the Silk Road, and studies of architecture on other Space Bodies.