This study investigated Teachers’ Awareness of Duty of Care and students’ Safety in Public Senior Secondary Schools in Rivers State. The purpose of the study was to examine between teachers’ awareness of duty of care and students’ safety in public senior secondary schools in Rivers State. Two research questions and two hypotheses were raised for the study. The study adopted the correlational design. The population of the study was 6,962 teachers from 302 public senior secondary schools in the three senatorial districts in Rivers State. The sample size was 360 teachers. The sample size was determined using Taro Yamene formula. The data were collected using two research instruments titled, Teachers’ Awareness of Duty of Care Questionnaire and Students’ Safety Questionnaire. The instrument was validated by three experts. The reliability of the instrument was established using Cronbach Alpha method. The reliability coefficient was 0.78. The data collected were analyzed using Pearson’s Product Moment Correlation Coefficient to answer the research question while t-test was used to test the hypotheses at 0.05 level of significance. The findings of the study reveal that, there is significant relationship between teachers’ awareness of negligence as teachers’ duty of care and school inspection and students’ safety. Based on the findings of the study, it was recommended that school management should organize workshop or seminars for teachers, to create awareness on their duty of care to avoid negligence because of its implications on students’ safety in public senior secondary schools and that school management should organize seminars for school teachers on the need for school inspection because it enhances students’ safety in public senior secondary schools.