Human resources in a company are an essential aspect that determines the effectiveness and success of a company. A company complete with facilities and infrastructure will be meaningless without humans as managers and idea loaders. This study analyzed the effect of job training, financial compensation, and career development on nurse performance. This research method is descriptive quantitative using the Cross-Sectional type, conducted in the inpatient room of Royal Prima Medan Hospital in 2023. The population is all nurses totaling 178 people; the technique of determining the number of samples is total sampling-data analysis using univariate, bivariate, and multivariate analysis. The results of research on job training variables (p-value 0.002, t-count 6.156 ≥ t-table 1.28), financial compensation (p-value 0.001, t-count 7.167 ≥ t-table 1.28), and career development (p-value 0.004, t-count 5.612 ≥ t-table 1.28) have a significant influence with a large p-value ≤ 0.05 and t-count greater than t table. The results of F count 78.422 ≥ F table 3.05 and significance 0.004 or smaller than α = 0.05, meaning that the variables of job training, compensation, and career development have a positive and significant effect on performance. The conclusion of the adjusted R Square value is 0.873, meaning that the ability of the independent variables to explain the variation of the dependent variable is 87.3%, and the remaining 12.7% is explained by independent variables not studied, such as work environment and motivation.