Government procurement of goods and services is the sector most vulnerable to fraud, especially fraud in the form of corruption. Viewed from the perspective of the subject of corruption, the perpetrators of corruption in the procurement of government goods and services can come from within the organization or from outside the organization. This research aims to examine the direct or indirect relationship between the use of e-procurement and top management support and preventing corruption in government procurement of goods and services through an internal control system. This research is research that is included in quantitative research. This research was conducted in the public sector, namely in the government goods and services procurement sector within the Ministry of Education, Culture, Research and Technology in Indonesia, involving 100 respondents, namely Functional Officials for Procurement of Goods and Services Management (JF PBJ). Sampling in this research used non-probability sampling with purposive sampling technique. The data analysis used in this research is descriptive analysis techniques, meanwhile the research hypothesis is tested using Partial Least Square (PLS) hypothesis testing. Based on the test results, it was found that the use of e-procurement, top management support and internal control systems have a direct effect on preventing corruption in government procurement of goods and services. The use of e-procurement and top management support has a direct effect on the internal control system. And the use of e-procurement and top management support indirectly influences the prevention of corruption in government procurement of goods and services through the internal control system.