This study investigates the impact of industrial output on environmental degradation in some selected ECOWAS countries from the year 2007 to 2020 for seven countries. The study employed Pedroni residual based approach of panel cointegration test to investigate the presence of long term relationship between industrial output and environmental pollution, which is proxied by CO₂ emission. The results of the study validate the presence of long-run relationship between industrial output and environmental pollution. In addition, the study used the fully modified Ordinary Least Square (FMOLS) model estimation technique to estimate the model The results obtained from the model from the estimation revealed that industrial output and Urban population have positive but not significant impact on the quantity of CO₂ emissions, while foreign direct investment and GDP have negative but insignificant impact on the quantity of CO₂ emission in the five selected West African countries. By implication, an increase in industrial output and urban population will increase the quantity CO₂ emissions on the environment and consequently causing environmental degradation in the West African countries.