The objective of the present study was to formulate sustained release matrix tablets of Tridax procumbens, for treatment of bacterial infections. The matrix tablets were prepared by direct compression method using hydroxyl propyl methyl cellulose K4M, sodium alginate in various concentrations. The powder showed satisfactory flow properties and compressibility. All the formulations showed acceptable pharmacopoeia standards. The result of formulation F1. Successful formulation was found stable after evaluation for physicochemical parameters when kept for 90 days at room temperature, 400c and 2-8 0 c. It concluded that sustained release matrix tablets of Tridax procumbens containing HPMC K4M and sodium alginate provide a better option for Sustained release of tridax.