The objective of present study was to develop matrix type transdermal therapeutic systems of Licorice using various polymers such as sodium alginate and HPMC as matrix formers. Results revealed that prepared patches showed good physical characteristics, no drug-polymer interaction and no skin irritation was observed. The in vitro release study revealed that F3 formulation showed maximum release in 8 hrs. Formulation F3 was subjected for accelerated stability studies. The F3 formulation was found to be stable as there was no drastic change in the Physicochemical properties of the patches, which was also confirmed by FTIR. Thus conclusion can be made that stable transdermal patches of Licorice has been developed. F3 formulation showed highest cumulative percentage drug release of 94.70 % were obtained during in vitro drug release studies after 8 hrs. The release of Licorice appears to be dependent on lipophilicity of the matrix. Moderately lipophillic matrices showed best release. The predominant release mechanism of drug through the fabricated matrices was believed to be by diffusion mechanism. Based upon the in vitro dissolution data the F3 formulation was concluded as optimized formulation.