Abstract

Introduction: The six-membered benzene bonded to the five-membered imidazole molecule is a basic structural feature of the benzimidazole group of heterocyclic, aromatic chemicals. The application of molecules with benzimidazole motifs in medical and biological studies has demonstrated promise. The study's objective was assessing the pharmacological activity of synthesised substances. 1-(1H-benzimidazol-2-yl)-2-(3-hydroxyphenyl) ethanone (AC) was investigated for its anthelmintic properties. The goal of this research was to evaluate the pharmacological activity of synthesised substances. 1-(1H-benzimidazol-2-yl)-2-(3-hydroxyphenyl) ethanone (AC) was investigated in vitro for its anthelmintic properties. Using IR, 1H-NMR, mass spectrometry, and elemental analysis, the purity of the synthesised compounds was identified.
Materials & methods: Formic acid; Acetyl Chloride; Benzene-1,2-diol; Glycolic Acid; Benzoyl Chloride; Methyl Chloride; Ethyl Chloride; Benzamide etc and method is TLC, IR spectra, 1H-NMR and MS. IR spectroscopic research proved the existence of a certain functional group. By using 1 H proton magnetic resonance, the structure of the synthesised molecules was determined. The derivatives' 
Results: The acquired results demonstrate that many active compounds at concentrations of 100 mg/mL in the compositions under investigation have been determined to be involved in the paralysis and death of earthworms, with paralysis occurring 20 minutes and death occurring 24 minutes afterwards. 
Conclusion: Although the derivatives of 1-(1H-benzimidazol-2-yl)-2-(3-hydroxyphenyl) ethanone (AC) demonstrated moderate to good anthelmintic activity, IV was determined to be the most potent agent against Pheretima posthuma. Compound IV's anthelmintic activity was found to be comparable to that of the positive control drug Albendazole.