Nature has invented reproduction as a mechanism for life to move forward. Every living system has been awarded a magical power to reproduce. In nature there are two kinds of reproduction, asexual and sexual reproduction. Human use sexual reproduction to bring their progeny in life. Humans who have fertile feels very lucky because 15-20% couple are infertile. Average incidence of infertility is about 15%, globally varies in different population.   According to Indian society of assisted reproduction, infertility currently affects about 10 to 14% of Indian population, with higher rate in urban area 1 out of 6 couple is impacted .  Nowadays some significant social, physical, psychological and medical factors are affecting couple adversely by inhibiting their power to reproduce. In this article author will shortly describe what is Infertility, Few Terms related to infertility Causes of infertility, what we will ask with male and female partner while history taking? Investigations and treatments.