This article is an attempt to show the deplorable situation of some vulnerable groups (women and girls; youths and children; pygmies; elderly persons and persons living with disabilities) in Cameroon. Despite the fact that Cameroon has ratified a good number of regional and international legal instruments as well as adopted some national legal instruments for the welfare of the said groups, its efforts to implement these legal requirements is still far below expectations in many domains. Consequently, it has to devise better ways and means of addressing issues dealing with the rights of these groups, ways and means which must be sought by all the stakeholders concerned (The vulnerable groups concerned, experts, authorities, etc).