The objective of present study was to develop Buccal therapeutic systems of Salbutamol sulphate using various such as Eudragit, Sodium alginate polymers as matrix formers. Results revealed that prepared patches showed good physical characteristics, no drug-polymer interaction was observed. The in vitro release study revealed that F2 formulation showed maximum release in 6hrs. Formulation F2 was subjected for accelerated stability studies. The F2 formulation was found to be stable as there was no drastic change in the Physico-chemical properties of the patches, which was also confirmed by FTIR. Thus conclusion can be made that stable Buccal patches of Salbutamol sulphate has been developed. F2 formulation showed highest cumulative percentage drug release of 96.89 % were obtained during in vitro drug release studies after 6 hrs. The release of Salbutamol sulphate appears to be dependent on lipophilicity of the matrix. Hydrophilic matrices showed best release. The predominant release mechanism of drug through the fabricated was believed to be by diffusion mechanism. Based upon the in vitro dissolution data the F2 formulation was concluded as optimized formulation.