Orally disintegrating tablets (ODTs) are a modern form of tablets that when placed in the oral cavity, disperses rapidly. These tablets have advantages, particularly good applications for children and old patients who have a complication in chewing or swallowing solid dosage forms. Rizatriptan is a drug of choice in treatment of migraine headaches. Drug compatibility with excipients was checked by FTIR studies. In the present work, oral dispersible tablets of Rizatriptan were prepared by direct compression method with a view to enhance patient’s compliance. To formulate oro dispersible tablets of Rizatriptan for rapid dissolution of drug and absorption, which may produce rapid onset of action in the treatment of motion sickness. Drug and excipient compatibility studies measured by using FTIR studies. Eight formulations having different concentrations of super disintegrants were prepared. These tablets were evaluated for drug content, weight variation, friability, hardness, wetting time and in vitro disintegration time. Among the formulations tablets of batch F5 containing Croscarmellose showed superior organoleptic properties along with excellent in-vitro disintegration time and drug release as compared to other formulations. Hence croscarmellose is recommended as suitable disintegrate for the preparation of direct compression or dispersible tablets of Rizatriptan. It was concluded that the presence of a super disintegrant is desirable for orodispersion of tablets by direct compression method.