State universities in the Philippines have long been a source of hope for underprivileged students, including those with visual impairments, who encounter a range of challenges in both their educational and daily community experiences. This multi-case study examined the similarities and differences of the experiences of three (3) college students with visual impairment regarding their educational challenges and opportunities faced in a public higher education institution in Cebu, Philippines. A semi-structured questionnaire consisting of probing and open-ended questions was utilized. It was analyzed using a cross-case analysis approach to identify the distinction between the educational challenges and opportunities they experienced on their learning journey. The findings showed that college students with visual impairment experienced five main challenges in higher education regarding accessibility, instruction, educational compliance, socialization, and assistive technology. Consequently, college students with visual impairment experienced opportunities only in accessibility, socialization, and assistive technologies. In conclusion, students with visual impairment have experienced 5varied challenges and opportunities in state universities in the Philippines. It is recommended that schools should enhance their services and resources to overcome the issues faced by students with visual impairments.