Diabetes mellitus is currently considered a common lifestyle disease. The study aims to investigate phytochemicals and evaluate the antidiabetic and anti-oxidative potency of Adansonii Monstera. The Adanson’s monstera flowers used in the study were collected from the herbal garden of our institution and authenticated by Sri Venkateshwara University. This study demonstrates that the ethanolic extract of Adanson’s monstera’s has promising antioxidant and antidiabetic activity to use for human health. The extract also has a very prominent antidiabetic effect to be used in many pharmacological as well as biological actions. Diabetic dyslipidemia is characterized by high TC, TG, low HDL, and high LDL. Consequently, the pharmacological and toxicity studies also proved the anti-diabetic potential of Adanson’s monstera’s could be a promising source of therapeutic demands.