Now a day’s acne is a common disease reported in the teenage population. Propionibacterium acnes and Staphylococcus epidermidis are responsible for the development of various forms of acne vulgaris. Acne is a chronic, inflammatory skin condition resulting in pimples and spot formation on the face, shoulders, back, neck, chest, and upper arms. It has both inflammatory (papules, pustules and nodules) and non-inflammatory (comedones, open and closed) lesions. In acne there occur involvements of the oil glands at the base of hair follicles. It can occur at any age but commonly seen at the time of puberty, when the sebaceous glands get activated. Sebaceous glands produce oil, on stimulation by male hormones which are produced by the adrenal glands in both males and female body. Acne vulgaris affects both self-esteem and psychosocial development of the person. Treatment of acne can be done by some thrapies such as topical, systemic, hormonal, herbal and combination therapy. In many cases, conventional treatment fails and the patients become helpless. Increased resistance has developed in acne causing bacteria, due of excessive use of antibiotics in its management for long durations. Detailed management of the disease is mentioned by Unani physicians in their classical literature which is safe and effective. These include number of single herbs and compound herbal formulas as well as dieto-therapy and other regimes.