Development and in vitro evaluation of Niosomal drug delivery system
Abstract
The present study was focused on formulating and evaluating Glipizide containing niosomes formulation for in vitro studies. Niosomal formulations were prepared by using different ratio of surfactant (Span 20 and span 80) and cholesterol by thin film hydration method and were evaluated for invitro characteristics, stability studies. Span 20 containing niosomal formulation displayed highest entrapment efficiency with desired particle size. SEM analyses showed that niosomal formulation was spherical in shape. Niosomes containing span 20 displayed higher percentage of drug release after 8h as compared to other formulations.F-1 formulation was found to be stable at the end of the study on storage condition. The present study suggested that niosomal formulations provide sustained and prolonged delivery of drug with enhance bioavailability.
How to Cite This Article
E Nikhil Chakravarth, Aligeti Ganesh, B Deekhithamani, LC Divyasri, Gundla Maheshwari (2024). Development and in vitro evaluation of Niosomal drug delivery system . International Journal of Multidisciplinary Research and Growth Evaluation (IJMRGE), 5(3), 419-423.