Formulation and evaluation of olmesartan medoxomil topical gel
Abstract
The objective of the study is to formulate and evaluate aolmesartanmidoxomiltopical gel for their skin infections. Four gel formulations were prepared using gelling agents HPMC (F1-F2) and carbopol (F3-F4) and they were evaluated for physical appearance, drug content, viscosity, extrudability, pH, spreadability, In vitro diffusion profile. The formulated gel showed good physical characteristics. The formulation F2 (96.96%) show good drug content as the polymer concentration in them was higher. The spread ability of gel decreases with an increase in polymer concentration. The pH of the formulation was in the range of 6-8 which is considered acceptable to avoid the risk of irritation upon application to the skin. Among the formulations, F2 showed better release (97.24%) characteristics than other formulations. The stability study for the topical gel formulation was done as per ICH guidelines Formulated gels were homogenous, stable and complied with the guidelines.
How to Cite This Article
Jhansi Lakshmi, Madavath Dasru, Guguloth Anusha, Muntasir Sirat, Bodapati Durga Prasad (2024). Formulation and evaluation of olmesartan medoxomil topical gel . International Journal of Multidisciplinary Research and Growth Evaluation (IJMRGE), 5(3), 442-446.