The objective of the study was to formulate and evaluate Mouth Dissolving Tablets of Naproxen Direct compression method was used to formulate orally disintegrating tablet of Naproxen by employing different super disintegrants, polymers, and magnesium stearate (lubricant), Talc. These prepared formulations were then evaluated. Dissolution and drug content tests were performed using USP apparatus II and ultraviolet spectrophotometry, respectively. All formulations showed compliance with pharmacopeia standards. The effect of super disintegrants concentration and direct compression method on drug release profile was studied. Release profile of F3 were found to be satisfactory comparing to other formulations. F3 Formulation as processed excipient was found to be the best super disintegrants for the preparation of Naproxen mouth dissolving tablets formulations. Due to it has exhibited faster disintegration time and best dissolution profile when compared to other formulations.