Abstract

To evaluate the literature regarding the effectiveness of autologous platelet rich fibrin (PRF) in periodontal hard tissue regeneration. The use of PRF in periodontal applications for its inexpensive and autologous material are promising. Each of these studies assessed indicated improved periodontal outcomes with the adjunctive use of PRF in Open flap debridement. All studies presented shows statistically significant differences for Intra bony defects, as measured on standardized radiographs read by computer aided software. After assessing the strength and validity of the available studies, the results presented were only in a moderately conclusive manner. Larger, longer termed longitudinal, multicentred randomized controlled clinical trials are required, which employ strong sampling techniques are needed to determine the effects of PRF on the regeneration on periodontal hard tissue. Once more of these studies are available, a systematic review should be conducted. Ongoing research together with review type publications will help clinicians form an evidenced based decision on the potential of PRF in regeneration of periodontal hard tissue.