Abstract

Mucoadhesive patches of Diclofenac sodium were prepared by solvent casting method. To develop mucoadhesive patches for buccal administration of Diclofenac sodium and evaluation. The Mucoadhesive buccal patches of Diclofenac sodium were formulated using HPMC (hydroxy propyl methyl cellulose) as polymer and Methanol as solvent. HPMC also helps in formation of Film. A full factorial design was used to design the experiments for each polymer combination. A total of six formulations were prepared.
All the patches were characterized by Physico-chemical evaluation. The prepared Patches were smooth, uniform in thickness, mass, drug content and showed no visible cracks or folds. Of these 15 formulations prepared 6 patches showed high folding endurance and these patches were selected for further evaluations such as thickness, surface pH, and uniformity weight and percentage moisture loss. These patches are best fitted to the Korsmeyer-Peppas model.