Mucoadhesive buccal patches of ondansetron were prepared for the prevention and treatment of chemotherapy-induced emesis. Films of varying polymeric composition were prepared in order to facilitate initial as well as prolonged drug release that could take care of acute as well as delayed emesis. Mucoadhesive buccal patches were prepared using polymers such as ethyl cellulose and eudragit. The effect of concentration of these polymers on physical properties and drug release were studied. All the films were prepared by solvent casting method. In another part of the study, the effect of drug concentration on physical and mucoadhesive properties of patch were assessed, keeping the polymer concentration fixed. Buccal patch containing eudragit showed good mucoadhesion. The study concluded that the developed buccal films have the potential to release ondansetron required for chemotherapy induced acute and delayed emesis.