Hospital services are an essential and inescapable component of contemporary society. The level of public awareness significantly influences the preference for the establishment of Sharia-compliant hospitals. To ensure the implementation of Sharia-compliant practices within hospitals, it is crucial to assess hospital performance effectively. One method for performance evaluation in this context is the Maqasid Sharia-based Performance Measurement System (PMMS), which is structured around three key dimensions: 1) Individual Education, 2) Justice Creation, and 3) Public Interest. This study specifically examines the financial performance of Muhammadiyah Hospital in Bandung in relation to Islamic Sharia principles. The research employs a mixed-methods approach, combining descriptive quantitative analysis of financial reports from 2017 to 2021 with qualitative data gathered from in-depth structured interviews with hospital directors, management, and through examination of relevant documents and financial reports. The data were analyzed using the Maqasid Shariah Concordance (MSC) Index and Quadrant Analysis Measurement (QAM) models. The findings of the QAM analysis reveal that the financial performance of Muhammadiyah Hospital in Bandung, according to Sharia Hospital Certification Standards, was positioned in Quadrants 3 and 4. In Quadrant 3 (Upper Left Quadrant, ULQ), the hospital exhibited low profitability but high alignment with Maqasid Sharia. Conversely, in 2021, the hospital’s performance shifted to Quadrant 4 (Upper Right Quadrant, URQ), indicating both high profitability and strong Sharia compliance.