Hospital service quality relies heavily on human resources, particularly nurses, whose performance is determined by effective nursing care, including assessment, diagnosis, planning, implementation, evaluation, and documentation. High performance requires strong work ethics—encompassing respect, compassion, advocacy, and interpersonal connection—and high affiliation motivation, characterized by friendship, cooperation, and reciprocal relationships. This study examined the implementation of work ethics, affiliation motivation, and their effects on nurse performance using a descriptive quantitative approach with multiple regression analysis, involving 119 respondents selected through total sampling. Results showed that nurses demonstrated high levels of work ethics, affiliation motivation, and performance. Work ethics moderately influenced performance by encouraging adherence to standards, while affiliation motivation had a stronger impact by fostering relationships that enhanced care delivery. Combined, work ethics and affiliation motivation significantly improved performance, highlighting their crucial role in ensuring quality healthcare at Dr. Hafiz Cianjur Hospital.