In supply chain management, the combination of Blockchain and Artificial Intelligence (AI) offers innovative solutions to address critical challenges, particularly in safeguarding financial transactions and reducing fraud. Blockchain’s decentralized and immutable nature, coupled with AI’s ability to analyze vast data sets and detect patterns, can create tamper-proof financial records and enhance trust in supply chain operations. Blockchain-backed smart contracts can automate processes, ensuring transparency, accountability, and efficiency in trade finance. These smart contracts execute predefined actions based on agreed conditions, and the integration of AI allows for real-time monitoring, risk assessment, and anomaly detection. This synergy enhances the security and reliability of trade finance transactions, significantly reducing the potential for fraud, errors, or disputes. AI can continuously analyze blockchain transaction data to identify fraudulent activities, unauthorized access, and discrepancies, further bolstering security. By leveraging these technologies together, supply chain networks can achieve greater operational efficiency, minimize financial risks, and ensure the integrity of financial records. This review explores the potential of blockchain and AI synergies in creating secure, transparent, and fraud-resistant trade finance ecosystems, highlighting their impact on reducing fraud and increasing overall supply chain reliability. The integration of these advanced technologies holds great promise for transforming global trade by enabling more secure, efficient, and trustworthy financial operations across interconnected supply chains.