Abstract

Personalized oncology care, which involves tailoring cancer treatment to an individual patient's unique genetic, environmental, and lifestyle characteristics, has gained momentum globally as an effective strategy for improving cancer outcomes. However, implementing personalized oncology care in Sub-Saharan Africa presents significant challenges due to resource constraints, limited healthcare infrastructure, and sociocultural diversity. This review explores the insights and challenges surrounding personalized oncology care in the region, highlighting both opportunities and barriers. Key challenges include limited access to advanced diagnostic tools, such as genomic sequencing, which are essential for developing personalized treatment plans. Inadequate healthcare infrastructure and a shortage of trained oncology specialists exacerbate the difficulty of implementing precision medicine. Financial constraints, both at the patient and systemic levels, further limit access to innovative therapies and technologies. Additionally, sociocultural factors, including stigma and lack of awareness about cancer, hinder patient engagement and adherence to treatment. Despite these obstacles, innovative solutions are emerging. Collaborative efforts between governments, non-governmental organizations (NGOs), and international partners are driving advancements in cancer research and care delivery. Investments in telemedicine, mobile health platforms, and regional research initiatives have shown promise in bridging gaps in access and knowledge. Furthermore, localized cancer registries and biobanks are providing critical data to inform context-specific approaches to treatment. To achieve sustainable personalized oncology care in Sub-Saharan Africa, strategic investments in healthcare infrastructure, capacity building, and partnerships are essential. Addressing disparities in access to diagnostics and treatments, while fostering community engagement, will be critical for improving cancer outcomes in this resource-constrained region. This review underscores the urgent need for coordinated efforts to make personalized oncology care a reality in Sub-Saharan Africa.