Progesterone plays a crucial role in supporting pregnancy through a variety of endocrinological and immunomodulatory functions. It promotes vascular growth in the endometrium, supports nutrient secretion for embryo development, and prepares the uterine lining for implantation. Progesterone's immunomodulatory properties are vital for preventing immune rejection of the fetus, as it suppresses the activation of immune cells and cytokine production, maintaining a suitable immune environment for pregnancy. A systematic literature review was conducted in this study about the herbal plants used in the preparation of Jīwanīya Ghana Kashaya and their pharmacological effects by using recent evidence published in the PUBMED Central database from 2000 to 2023. The PRISMA model was applied in selecting the relevant publications. The herbs in Jīwanīya Ghana Kashaya, exhibit diverse pharmacological activities that could aid in preventing miscarriage. These herbs display anti-inflammatory, antioxidant, and immunomodulatory effects by modulating key cytokines and signalling pathways involved in immune responses. For instance, Leptadenia reticulata inhibits prostaglandins and reduces inflammation by regulating cytokines like IL-2 and TNF-α. Withania somnifera suppresses NF-kB activity and reduces NO production, while Asparagus racemosus boosts antioxidant enzymes and modulates the immune system. Pueraria tuberosa and Glycyrrhiza glabra further reduce inflammation and oxidative stress by inhibiting pro-inflammatory cytokines and enhancing antioxidant activity. Notably, Jīwanīya Ghana Kashaya may target multiple signalling pathways like TNF, TLR4, and MAPK, contributing to its potential in mitigating the effects of spontaneous abortion. These findings highlight the therapeutic potential of these herbs in managing pregnancy- related complications such as spontaneous abortion.