The research (study) investigates the impact of tobacco smoking on complete blood count (CBC) parameters among students at This study examines the influence of tobacco cigarette smoking on complete blood count (CBC) parameters among students at Sarhad University of Science and Information Technology (SUIT) in Peshawar. The research aims to know and investigate the prevalence of smoking in students and identify which CBC parameters are most affected by smoking. A descriptive cross-sectional study was conducted over six months, involving 30 undergraduate male smokers. Blood samples were collected and analyzed using an automated hematology analyzer to measure various CBC parameters, including WBC, RBC, Hb, HCT and platelets. The results revealed significant changes in CBC parameters among smokers. Notably, elevated WBC and RBC counts were the most significant findings. Specifically, 17 out of the 30 respondents exhibited high WBC counts (greater than 11.00 cells/uL), and 18 respondents showed elevated RBC counts (greater than 6 million cells/uL). Hemoglobin and hematocrit levels were mostly within the normal range, while platelet counts were also generally normal, with only one respondent showing elevated levels. These study and investigation suggest that cigarette has a detrimental effect on hematological parameters, potentially increasing the risk of inflammation, immune dysfunction, and circulatory disorders. The study emphasizes the importance of smoking cessation and regular health monitoring to mitigate these adverse effects. Recommendations include adopting healthier lifestyles, seeking professional support for smoking cessation, and conducting further longitudinal studies with larger sample sizes to explore the long-term impacts of smoking on CBC parameters. Sarhad University of Science and Information Technology (SUIT) in Peshawar. The research aims to determine and analyze the prevalence of smoking (cigarette) in students and identify the CBC parameters most affected by smoking. A descriptive cross-sectional study was conducted over six months, involving 30 undergraduate male smokers. Blood samples were collected and analyzed using an automated hematology analyzer to measure CBC parameters, including WBC, RBC, Hb, HCT and platelets. The results revealed significant alterations in CBC parameters among smokers, with elevated WBC and RBC counts being the most notable changes. Specifically, 17 out of 30 respondents exhibited high WBC counts (>11.00 cells/uL), and 18 respondents showed elevated RBC counts (>6 million cells/uL). Hemoglobin and hematocrit levels were mostly within the normal range, while platelet counts were also generally normal, with only one respondent showing elevated levels. The findings suggest that smoking adversely affects hematological parameters, potentially increasing the risk of inflammation, immune dysfunction, and circulatory disorders. The study known us the smoking cessation and regular health monitoring to mitigate these effects. Recommendations include adopting healthier lifestyles, seeking professional support for smoking cessation, and conducting further longitudinal studies with larger sample sizes to explore the long-term impacts of smoking on CBC parameters.