Effect of Tobacco Cigarette Smoking on Complete Blood Count (CBC) among Students of Sarhad University of Science & Information Technology, Peshawar
Abstract
The research (study) investigates the impact of tobacco smoking on complete blood count (CBC) parameters among students at This study examines the influence of tobacco cigarette smoking on complete blood count (CBC) parameters among students at Sarhad University of Science and Information Technology (SUIT) in Peshawar. The research aims to know and investigate the prevalence of smoking in students and identify which CBC parameters are most affected by smoking. A descriptive cross-sectional study was conducted over six months, involving 30 undergraduate male smokers. Blood samples were collected and analyzed using an automated hematology analyzer to measure various CBC parameters, including WBC, RBC, Hb, HCT and platelets. The results revealed significant changes in CBC parameters among smokers. Notably, elevated WBC and RBC counts were the most significant findings. Specifically, 17 out of the 30 respondents exhibited high WBC counts (greater than 11.00 cells/uL), and 18 respondents showed elevated RBC counts (greater than 6 million cells/uL). Hemoglobin and hematocrit levels were mostly within the normal range, while platelet counts were also generally normal, with only one respondent showing elevated levels. These study and investigation suggest that cigarette has a detrimental effect on hematological parameters, potentially increasing the risk of inflammation, immune dysfunction, and circulatory disorders. The study emphasizes the importance of smoking cessation and regular health monitoring to mitigate these adverse effects. Recommendations include adopting healthier lifestyles, seeking professional support for smoking cessation, and conducting further longitudinal studies with larger sample sizes to explore the long-term impacts of smoking on CBC parameters. Sarhad University of Science and Information Technology (SUIT) in Peshawar. The research aims to determine and analyze the prevalence of smoking (cigarette) in students and identify the CBC parameters most affected by smoking. A descriptive cross-sectional study was conducted over six months, involving 30 undergraduate male smokers. Blood samples were collected and analyzed using an automated hematology analyzer to measure CBC parameters, including WBC, RBC, Hb, HCT and platelets. The results revealed significant alterations in CBC parameters among smokers, with elevated WBC and RBC counts being the most notable changes. Specifically, 17 out of 30 respondents exhibited high WBC counts (>11.00 cells/uL), and 18 respondents showed elevated RBC counts (>6 million cells/uL). Hemoglobin and hematocrit levels were mostly within the normal range, while platelet counts were also generally normal, with only one respondent showing elevated levels. The findings suggest that smoking adversely affects hematological parameters, potentially increasing the risk of inflammation, immune dysfunction, and circulatory disorders. The study known us the smoking cessation and regular health monitoring to mitigate these effects. Recommendations include adopting healthier lifestyles, seeking professional support for smoking cessation, and conducting further longitudinal studies with larger sample sizes to explore the long-term impacts of smoking on CBC parameters.
How to Cite This Article
Ahmad Khan, Aamir Zada, Shumaila Ijaz, Shakir Ullah, Shakil Ahmad (2025). Effect of Tobacco Cigarette Smoking on Complete Blood Count (CBC) among Students of Sarhad University of Science & Information Technology, Peshawar . International Journal of Multidisciplinary Research and Growth Evaluation (IJMRGE), 6(2), 1003-1015.
References
- 1. Abel GA, Hays JT, Decker PA, Croghan GA, Kuter DJ, Rigotti NA. Effectsofbiochemicallyconfirmedsmokingcessationonwhitebloodcellcount. Mayo Clinic Proceedings.2005;80(8\:10228.
- 2. Aftab K, Al Shammari M. Impactofnicotineonhematologicalparametersanditscomparativestudiesonactiveandpassivesmokers. European Journalof Pharmaceuticaland Medical Research.2015;2(6\:7982.
- 3. Al-Turki YA. Smokinghabitsamongmedicalstudentsin Central Saudi Arabia. Saudi Medical Journal.2006;27(5\:7003.
- 4. Anthonisen N. Theeffectsofasmokingcessationinterventionon14.5-yearmortality-response. Annalsof Internal Medicine.2005;143(8\:615.
- 5. Asadikaram G, Asiabanha M, Sayadi A, Jafarzadeh A, Hassanshahi G. Impactofopiumontheserumlevelsof TGF-tic, addictedandaddicted-diabeticrats. Iranian Journalof Immunology.2010;7(3\:18692.
- 6. Asif M, Karim S, Umar Z, Malik A, Ismail T, Chaudhary A, Hussain Alqahtani M, Rasool M. Effectofcigarettesmokingbasedonhematologicalparameters: comparisonbetweenmalesmokersandnon-smokers. Turkish Journalof Biochemistry/Turk Biyokimya International Journalof Multidisciplinary Researchand Growth Evaluationwww. allmultidisciplinaryjournal. com1014|Page Dergisi.2013;38(1\:7580.
- 7. Aula FA, Qadir FA. Effectsofcigarettesmokingonsomeimmunologicalandhematologicalparametersinmalesmokersin Erbil City. Jordan Journalof Biological Sciences.2013;6(2\:14750.
- 8. Batool F, Malik K, Meraj L, Tariq KM, Iqbal T, Zaka N. Frequencyofraisedmeanplateletvolumeinpatientswithacutecoronarysyndromein HITHospital Taxila. Journalof Rawalpindi Medical College.2023;27(2\:2169.
- 9. Bhadarge G, Ambad R, Bankar N, Kotecha R. Studyofcigarettesmokingonhaematologicalparametersandlipidprofilein Vidharbharegion, India. Journalof Pharmaceutical Research International.2021;33(43B\:2137.
- 10. Boehm RE, Arbo BD, Leal D, Hansen AW, Pulcinelli RR, Thiesen FV, Balsan AM, Onsten TG, Gomez R. Smokingfewerthan20cigarettesperdayandremainingabstinentformorethan12hoursreducescarboxyhemoglobinlevelsinpackedredbloodcellsfortransfusion. PLOSONE.2018;13(9\: e0204102.11.?ifofsmokingonhematologicalparametersandferritinlevels. Haseki Tip Bulteni Medical Bulletinof Haseki.2019;57(4\:2916.
- 12. Doll R, Peto R, Hall E, Wheatley K, Gray R. Mortalityinrelationtoconsumptionofalcohol:13years'observationsonmale Britishdoctors. BMJ.1994;309(6959\:9118.
- 13. Eiras S, Teijeira-Fern?ndez E, Shamagian LG, Fernandez AL, Vazquez-Boquete A, Gonzalez-Juanatey JR. Extensionofcoronaryarterydiseaseisassociatedwithincreased IL-6anddecreasedadiponectingeneexpressioninepicardialadiposetissue. Cytokine.2008;43(2\:17480.
- 14. Elisia I, Lam V, Cho B, Hay M, Li MY, Yeung M, Bu L, Jia W, Norton N, Lam S. Theeffectofsmokingonchronicinflammation, immunefunctionandbloodcellcomposition. Scientific Reports.2020;10(1\:19480.
- 15. Ernst E. Smoking, acauseofbacktrouble?Rheumatology.1993;32(3\:23942.
- 16. Fern?ndez JAF, Prats JM, Artero JVM, Mora AC, Fari?as AV, Espinal A, M?ndez JAG. Systemicinflammationin222,841healthyemployedsmokersandnonsmokers: whitebloodcellcountandrelationshiptospirometry. Tobacco Induced Diseases.2012;10:18.
- 17. Gitte RN. Effectofcigarettesmokingonplasmafibrinogenandplateletcount. Asian Journalof Medical Sciences.2011;2(3\:1814.
- 18. Hussain MS, Hamid NM, Al-Ani MQ, Muden BK, Hamad-Allah MJ, Sweed OH, Sabbar SS. Hematologicalchangesinbloodofsmokersofcigarettesandnargyle. Indian Journalof Forensic Medicineand Toxicology.2020;14(2\:17716.19. saoglu Z, Demir H, Karadag B. Effectsofsmokingonhealthyyoung Istanbul.2014;1(1\:1922.
- 20. Islam MM, Amin MR, Begum S, Akther D, Rahman A. Totalcountofwhitebloodcellsinadultmalesmokers. Journalof Bangladesh Societyof Physiologist.2007;2:4953.
- 21. Jaafar NS. Theeffectofcigarettesmokingonbloodandbiochemicalparameters: Acomparativestudyamongmalesmokersandnon-smokersin Baghdad City. Iraqi Journalof Science.2020;72731.
- 22. Karam GA, Rashidinejad HR, Aghaee MM, Ahmadi J, Rahmani MR, Mahmoodi M, etal. Opiumcandifferentlyalterbloodglucose, sodiumandpotassiuminmaleandfemalerats. Pakistan Journalof Pharmaceutical Sciences.2008;21(2\:1804.
- 23. Khan MS. Relationshipofsmokingwithalterationinbodyphysiology. Biomedical Letters.2022;8(2\:17783.
- 24. Kume A, Kume T, Masuda K, Shibuya F, Yamazaki H. Dose-dependenteffectsofcigarettesmokeonbloodbiomarkersinhealthy Japanesevolunteers: observationsfromsmokingandnon-smoking. Journalof Health Science.2009;55(2\:25964.
- 25. Liang X, Liu R, Chen C, Ji F, Li T. Opioidsystemmodulatestheimmunefunction: areview. Translational Perioperativeand Pain Medicine.2016;1(1\:5.
- 26. Liu Z, Li X, Zhang M, Huang X, Bai J, Pan Z, etal. Theroleof Mean Platelet Volume/plateletcount Ratioand Neutrophilto Lymphocyte Ratioontheriskof Febrile Seizure. Scientific Reports.2018;8(1\:15123.
- 27. Malenica M, Prnjavorac B, Bego T, Dujic T, Semiz S, Skrbo S, etal. Effectofcigarettesmokingonhaematologicalparametersinhealthypopulation. Medical Archives.2017;71(2\:132.
- 28. Mj?s OD. Lipideffectsofsmoking. American Heart Journal.1988;115(1\:2725.
- 29. Mohamed SE, Eid HA, Moazen EM, El-Fattah A, Doaa A. Impactofchroniccigarettesmokingonbloodcountindices, erythrocytesedimentationrateand C-reactiveproteinasinflammatorymarkersinhealthyindividuals. Journalof Recent Advancesin Medicine.2023;4(1\:7485.
- 30. Monti M, Monti A, Murdolo G, Di Renzi P, Pirro MR, Borgognoni F, etal. Correlationbetweenepicardialfatandcigarettesmoking: CTimaginginpatientswithmetabolicsyndrome. Scandinavian Cardiovascular Journal.2014;48(5\:31722.
- 31. Okafor I, Okoroiwu H. Effectsoftobaccocigarettesmokingonsomehematologicalparametersofmalecigarettesmokersin Southern Nigeria. Asian Journalof Medicineand Health.2017;5(3\:16.
- 32. Al-temimi SQ. Theeffectofcigarettesmokingonsomebloodparameters, bloodpressureandrenalfunctiontest. Journalof Kerbala University.2017;13(1\:110.
- 33. Raupach T, Shahab L, Baetzing S, Hoffmann B, Hasenfuss G, West R, etal. Medicalstudentslackbasicknowledgeaboutsmoking: findingsfromtwo Europeanmedicalschools. Nicotineand Tobacco Research.2009;11(1\:928.
- 34. Sajadian S, Vatankhah M, Majdzadeh M, Kouhsari SM, Ghahremani MH, Ostad SN. Cellcyclearrestandapoptogenicpropertiesofopiumalkaloidsnoscapineandpapaverineonbreastcancerstemcells. Toxicology Mechanismsand Methods.2015;25(5\:38895.
- 35. Saqib MAN, Rafique I, Qureshi H, Munir MA, Bashir R, Arif BW, etal. Burdenoftobaccoin Pakistan: findingsfromglobaladulttobaccosurvey
- 2014. Nicotineand Tobacco Research.2018;20(9\:113843.
- 36. Schuler M, Muehlbauer P, Guzzie P, Eastmond D. Noscapinehydrochloride-inducednumericalaberrationsinculturedhumanlymphocytes: acomparisonof FISHdetectionmethodsandmultipleend-points. International Journalof Multidisciplinary Researchand Growth Evaluationwww. allmultidisciplinaryjournal. com1015|Page Mutagenesis.2003;18(3\:23542.
- 37. Stefanadis C, Tsiamis E, Vlachopoulos C, Stratos C, Toutouzas K, Pitsavos C, etal. Unfavorableeffectofsmokingontheelasticpropertiesofthehumanaorta. Circulation.1997;95(1\:318.
- 38. Swaminathan A, Amitkumar K, Ganapathy S, Ayyavoo S. Evaluationoftheimpactofcigarettesmokingonplateletparameters. National Journalof Physiology, Pharmacyand Pharmacology.2015;5(5\:427.
- 39. Tarazi IS, Sirdah MM, El Jeadi H, Al Haddad RM. Doescigarettesmokingaffectthediagnosticreliabilityof Analysis.2008;22(2\:11922.
- 40. Torresde Heens G, Kikkert R, Aarden LA, Van Der Velden U, Loos BG. Effectsofsmokingontheexvivocytokineproductioninperiodontitis. Journalof Periodontal Research.2009;44(1\:2834.
- 41. Tsai M, Byun MK, Shin J, Crotty Alexander LE. Effectspulmonaryphysiology. The Journalof Physiology.2020;598(22\:503962.
- 42. Tulgar Y, Cakar S, Tulgar S, Dalkilic O, Cakiroglu B, Uyanik B. Theeffectofsmokingonneutrophil/lymphocyteandplatelet/lymphocyteratioandplateletindices: aretrospectivestudy. European Reviewfor Medicaland Pharmacological Sciences.2016;20(14\.
- 43. Wannamethee SG, Lowe GD, Shaper AG, Rumley A, Lennon L, Whincup PH. Associationsbetweencigarettesmoking, pipe/cigarsmoking, andsmokingcessation, andhaemostaticandinflammatorymarkersforcardiovasculardisease. European Heart Journal.2005;26(17\:176573.
- 44. World Health Organization. WHOreportontheglobaltobaccoepidemic2011: warningaboutthedangersoftobacco. e Scholarship, Universityof California.2011.45. elevatedmonocyteto HDLcholesterolratioassociatedwithsmoking. Journalof Clinical Medicine.2018;7(4\:76.