In an era where cybersecurity threats are escalating in complexity and frequency, enterprises face mounting pressure to ensure regulatory compliance while safeguarding critical digital assets. Traditional project management approaches often struggle to adapt to the dynamic and multifaceted nature of cybersecurity compliance, particularly within large and complex organizations. This study explores Project Management Innovations as a strategic enabler for strengthening cybersecurity compliance across such enterprises. The research introduces a hybrid project management framework that blends Agile, Waterfall, and DevSecOps methodologies to create a responsive, secure, and compliance-oriented project environment. The proposed framework emphasizes three key innovations: Compliance-Integrated Planning, Continuous Risk Assessment, and Collaborative Governance Structures. Compliance-Integrated Planning incorporates regulatory requirements such as NIST, ISO/IEC 27001, GDPR, and CMMC from the inception phase of projects, ensuring that security and compliance considerations are embedded in project objectives and deliverables. Continuous Risk Assessment leverages predictive analytics and automated compliance tools to identify, prioritize, and mitigate risks in real-time. Collaborative Governance Structures foster cross-functional engagement among cybersecurity teams, project managers, legal advisors, and compliance officers, ensuring alignment and accountability throughout the project lifecycle. A multi-case analysis was conducted across diverse enterprise sectors—including finance, healthcare, and energy—to evaluate the effectiveness of the model. Results indicate significant improvements in compliance readiness, with a 42% reduction in audit non-conformities and a 30% acceleration in security policy implementation timelines. Furthermore, the approach improved stakeholder communication and increased the visibility of compliance status across all project stages. This research contributes to both the fields of project management and cybersecurity by presenting a novel, integrative approach to regulatory adherence. It underscores the importance of adaptive project governance, cross-functional collaboration, and proactive compliance management in securing enterprise environments. By aligning project management practices with cybersecurity goals, the model equips enterprises to navigate evolving threat landscapes while maintaining compliance with global regulatory standards.