This paper examines the transformative potential of artificial intelligence (AI) in optimizing academic administration within Nigerian universities. With increasing enrollment pressures and resource constraints, Nigerian institutions stand to benefit significantly from AI-driven solutions for workflow automation, data management, and decision support. The study analyses current AI adoption trends in Nigerian higher education, evaluates relevant tools for local implementation, and proposes a framework for sustainable integration. Drawing on recent case studies from both global and emerging African contexts, the paper identifies key success factors and implementation challenges specific to Nigeria's educational landscape. The paper concludes with policy recommendations for Nigerian universities seeking to harness AI's potential while addressing infrastructure limitations and workforce adaptation concerns.