This study explores the relationship between EFL students’ personality traits and their preferred language learning styles at Nam Can Tho University. Rooted in the Five-Factor Model, namely Openness, Conscientiousness, Extraversion, Agreeableness, and Neuroticism, the research aims to identify how these psychological characteristics influence students' learning preferences. Employing a mixed-methods approach, the study gathered data through questionnaires and semi-structured interviews with 278 English-major students. Quantitative findings revealed statistically significant correlations between several traits and specific learning style: Extraversion and Agreeableness were linked to social and Auditory preferences; Conscientiousness correlated with structured and Visual learning style; while Openness showed the strongest associations across a wide range of learning styles. In contrast, Neuroticism did not exhibit consistent relationships with any learning styles. Qualitative data further supported these results by providing in-depth insights into students’ learning behaviors and motivations. The study highlights the importance of personality-informed pedagogy in English language instruction, suggesting that more personalized and learner-centered teaching strategies can lead to improved engagement and academic success among EFL students in Vietnam.