The Society 5.0 era introduces substantial transformations in education, prompting Indonesia to embrace the learner-centered Merdeka Curriculum and the incorporation of technology in instruction. The purpose of this study is to design and evaluate the validity and practicality of a flipped guided inquiry learning (FGIL) model, integrated with the Discord application, for acid-base subject matter. This study employs the Educational Design Research (EDR) methodology utilizing Plomp’s development framework. The research participants included chemistry lecturers and teachers serving as validators, along with nine students from the phase F class at SMAN 8 Padang. Content and construct validity were evaluated using Aiken's V, whilst practicality was examined by questionnaires administered to teachers and learners. The investigation revealed an average V value of 0.89 for both content validity and construct validity, which is classified as valid. Meanwhile, the practicality analysis results showed a percentage of 93%, based on the assessments of students and teachers, which is classified as very practical. The findings of this study showed that the proposed learning system possesses considerable potential to enhance the quality of chemistry education, thereby serving as a creative solution that aligns with the requirements of the Society 5.0 era and the actual implementation of the Merdeka Curriculum.