The main purpose of the study was to develop Hydrochlorothiazide floating tablets via non-effervescent technique using various polymers by direct compression. Before compression, the particulate powdered mixture was evaluated for pre-compression parameters. Compatibility among the formulation components was assessed by FTIR studies. FTIR studies revealed no interaction between the drug and polymers used. The prepared Hydrochlorothiazide tablets were evaluated for post-compression parameters, swelling index, floating lag time, in vitro buoyancy studies, and in vitro drug release studies. Optimized formulation (F4) revealed that tablet was constantly floating in the stomach region of the rabbit, thereby indicating improved gastric retention time for more than 8 hr. Consequently, all the findings and outcomes have showed that developed Hydrochlorothiazide floating tablets could be effectively used for floating drug delivery system.