Mouth dissolving tablets (MDTs) are a modern form of tablets that when placed in the oral cavity, disperses rapidly. These tablets have advantages, particularly good applications for children and old patients who have a complication in chewing or swallowing solid dosage forms. Drug compatibility with excipients was checked by FTIR studies. In the present work, oral dispersible tablets of Meloxicam category of NSAIDS were prepared by direct compression method with a view to enhance patient’s compliance. Drug and excipient compatibility studies measured by using FTIR studies. Eight formulations having different concentrations of super disintegrates such as Croscaramellose and Sodium starch glycolate were prepared. The pure drug and formulation blend was examined for angle of repose, bulk density, tapped density, Compressibility index and Hauser’s ratio. These tablets were evaluated for drug content, weight variation, friability, hardness, wetting time and in vitro disintegration time. Among the formulations tablets of batch F4 containing croscarmellose showed superior organoleptic properties along with excellent in-vitro disintegration time and drug release as compared to other formulations. Hence Croscarmellose is recommended as suitable disintegrate for the preparation of direct compression mouth dissolving tablets of Meloxicam. It was concluded that the presence of a super disintegrate is desirable for orodispersion of tablets by direct compression method.