Abstract

The global pharmaceutical industry faces growing threats from counterfeit and substandard drugs, undermining public health, regulatory compliance, and supply chain trust. To address these challenges, this paper evaluates the efficacy of DIDChain-enabled blockchain frameworks, which integrate Decentralized Identifiers (DIDs) with distributed ledger technology to establish real-time provenance verification and anti-counterfeit control. Drawing on a comprehensive body of literature, including conceptual frameworks in digital transformation, cybersecurity, business intelligence, and cloud-based analytics, the study explores how DIDChain infrastructure can enhance transparency, immutability, and interoperability in pharmaceutical logistics. The analysis incorporates findings from prior research on AI-driven fraud detection, supply chain resilience, and data governance models, particularly those applied in the financial, energy, and SME sectors. The evaluation highlights the role of DIDChain in supporting secure product authentication, automated compliance auditing, and cross-border regulatory coordination. This research contributes to emerging discourse on digital trust technologies, offering a scalable and interoperable solution for ensuring drug integrity in complex and globalized pharmaceutical ecosystems.